Volume 41, Issue 1 (Journal of Advanced Materials-Spring 2022)                   2022, 41(1): 1-17 | Back to browse issues page

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Dehghani Firoozabadi F, Ramazani Saadatabadi A, Asefnejad A. EVALUATION OF ANTIBACTERIAL PROPERTIES OF POLYLACTIC ACID-POLYCAPROLACTONE-CONTAINING HYDROXYAPATITE AND ZINC OXIDE NANOPARTICLES IN HARD TISSUE ABSORBABLE SCAFFOLDS. Journal of Advanced Materials in Engineering (Esteghlal) 2022; 41 (1) :1-17
URL: http://jame.iut.ac.ir/article-1-1176-en.html
EVALUATION OF ANTIBACTERIAL PROPERTIES OF POLYLACTIC ACID-POLYCAPROLACTONE-CONTAINING HYDROXYAPATITE AND ZINC OXIDE NANOPARTICLES IN HARD TISSUE ABSORBABLE SCAFFOLDS
F. Dehghani Firoozabadi , A. Ramazani Saadatabadi * , A. Asefnejad
Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran , ramazani@sharif.edu
Abstract:   (1189 Views)
Today, many people need to use bone grafts and implants because of damage to bone tissue. Due to the stimulation of the immune system after implantation, infection at the operation site is very common, which causes swelling and pain in the operation area. The use of zinc oxide nanoparticles reduces infection at the operation site and reduces the patient's need for antibiotics. In the present study, the morphology of the scaffolds was investigated by field emission scanning electron microscope (FE-SEM). The toxicity of the samples was evaluated using MTT assay. The behavior of nanocomposites against Escherichia coli and Staphylococcus aureus was investigated by measuring the diameter of the growth inhibition zone. It was found that modification of scaffolds with nanoparticles caused a growth inhibition in bacterial culture medium. It was also observed that fibroblast cells on the surface of the modified scaffolds had longer survival than polymer scaffolds. This study showed that the addition of oxidizing nanoparticles improves the antibacterial properties of scaffolds and cell viability and reduces scaffold toxicity.
Keywords: Hydroxyapatite, Zinc oxide, Antibacterial, Escherichia coli, Staphylococcus aureus.
Full-Text [PDF 1711 kb]   (595 Downloads)    
Type of Study: Research | Subject: Biomaterials
Received: 2021/11/1 | Accepted: 2022/03/9 | Published: 2022/08/1
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