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Showing 3 results for Nanofibers
Fabrication of Chitosan/Poly (vinyl alcohol)/Carbon Nanotube/Bioactive Glass Nanocomposite Scaffolds for Neural Tissue Engineering
S. Nikbakht Katouli, A. Doostmohammadi, F. Esmaeili,
Volume 35, Issue 1 (6-2016)
Abstract

The aim of this study was to fabricate carbon nanotube (CNT) and bioactive glass nanoparticles (BG) (at levels of
5 and 10 wt%) incorporated electrospun chitosan (CS)/polyvinyl alcohol (PVA) nanofibers for potential neural tissue engineering applications.The morphology, structure, and mechanical properties of the formed electrospun fibrous mats were characterized using scanning electron microscopy (SEM) and mechanical testing, respectively. In vitro cell culture of embryonal carcinoma stem cells (P19) were seeded onto the electrospun scaffolds. The results showed that the incorporation of CNTs and BG nanoparticles did not appreciably affect the morphology of the CS/PVA nanofibers. The maximum tensile strength (7.9 MPa) was observed in the composite sample with 5 %wt bioactive glass nanoparticles. The results suggest that BG and CNT-incorporated CS/PVA nanofibrous scaffolds with small diameters, high porosity, and promoted mechanical properties can potentially provide many possibilities for applications in the fields of neural tissue engineering and regenerative medicine.


Effect of Hydroxyapatite Nanoparticles on Properties of Keratin/Poly Caprolactone Nanofibers for Tissue Engineering
M. Mirhaj, M. Mahmoodi, A. Shybani,
Volume 36, Issue 4 (3-2018)
Abstract
In this research, keratin (Kr)/ poly caprolactone (PCL)/ hydroxyapatite (HA) scaffold was made by electrospinning method. Then, the effect of HA nanoparticles on properties of scaffold B (Kr 33%, PCL 50% and HA 17%) and scaffold A (Kr 40% and PCL 60%) were studied. The surface morphology, functional groups on the surface of samples, porosity, and specific surface area were evaluated by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectrophotometer (FTIR), liquid displacement method, and BET test, respectively. The mean diameter of fibers in samples A and B was measured 184 nm and 108 nm, respectively. Results showed that the  specific surface area in scaffolds with HA nanoparticles was almost 2 times higher than that of the scaffold without HA. The biodegradability of scaffolds was examined in phosphate buffer solution (PBS) and the results showed an increase in the weight loss percentage of the scaffold B. The cell viability and adherence of osteosarcoma cell line (Saos-2) on the scaffold surface was observed via MTT assay and the results showed an increase in cell growth on PCL/Kr scaffolds with HA nanoparticles. Thus, scaffolds containing HA nanoparticles can be a good choice for tissue engineering applications.

Investigating the Release of Methotrexate and 5-Fluorouracil Anticancer Drugs from Multi-Layered Nanofiber Structure of Polycaprolactone/Chitosan
N. Poursharifi, D. Semnani, P. Soltani, S. Amanpour,
Volume 38, Issue 4 (1-2020)
Abstract
In this study, seven-layer nanofiber structures consisting of polycaprolactone/ chitosan polymers loaded with methotrexate and 5-fluorouracil anti-cancer drugs, for controlled drug delivery, were produced and evaluated. For this purpose, the second, fourth and sixth layers were loaded with drug and placed between the drug-free layers. The surface morphology of drug-free and drug-loaded nanofibers was investigated by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR) was used to study their chemical structure. The drug release rate in phosphate buffered saline (pH=7.4) and the released drug concentration were measured by spectrophotometry. Mechanical properties of single- and multi-layered samples were also investigated. SEM images showed formation of uniform and beadless fibers. FTIR spectrum confirmed presence of the drugs in the polymer mixture with no interaction. It was found that by increasing the chitosan content, a brittle structure with decreased elongation is formed. The release behavior of methotrexate and 5-Fluoracil drugs in neutral pH environment for 26 days was evaluated and the results exhibited a slow and sustained release.

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