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Showing 3 results for Antibacterial
Preparation, Characterization and Comparative Study of Antibacterial Properties of Ag-TiO2 and ZnO-TiO2 Nanoparticles
S. Yazdkhasti, A. Monshi, A. Doostmohammadi,
Volume 34, Issue 4 (3-2016)
Abstract

With various features such as strong oxidation, biocompatibility and acceptable mechanical properties, titanium dioxide (TiO2) is among the materials that are frequently used in biological and medical applications. Nowadays, with the aim of increasing the efficiency of titanium dioxide and practical use of this material, doping it with elements such as silver, zinc and iron has been favored. In this study, Ag-TiO2 and ZnO-TiO2 nanoparticles were prepared by the sol–gel method and were evaluated and compared.In order to identify the present phases in the structure, X-ray diffraction analysis was used. Also for the characterization of the nanoparticles, Ultraviolet–visible spectroscopy (UV-Vis), Energy-dispersive X-ray spectroscopy (EDS), Field Emission Scanning Electron Microscope (FESEM) and Zeta Potential were used. Inaddition, the antibacterial activities of nanoparticles were investigated and compared. The results showed that sol-gel method could successfully produce nanoparticles of Ag-TiO2 and ZnO-TiO2 with the expected combination. The investigation of antibacterial properties of these particles revealed that at lower inhibitory concentrations, Ag-TiO2 composition has a higher antibacterial activity than ZnO-TiO2 one.


Influence of Cu Element on Degradation Rate and Biological Properties of Mg-Al-Cu Alloy Prepared by Spark Plasma Sintering
N. Safari, M. Toroghinejad, M. Kharaziha, V. Saeedi,
Volume 38, Issue 3 (12-2019)
Abstract
The aim of this study was to fabricate the Mg-1Al-Cu alloys with various amounts of Cu content (0, 0.25, 0.5 and 1 wt.%) using spark plasma sintering (SPS) approach and evaluation of their degradation rate and biological properties. The results indicated that Cu incorporation (0.25 wt.%) significantly diminish degradation rate from 0.039 cm/h in pure Mg to 0.00584 cm/h in Mg-1Al-0.25Cu alloy. In addition, Mg-1Al-0.25Cu alloy could noticeably (1.25 times) promote viability of MG63 cells compared to pure Mg, owing to the optimized ion release. Moreover, the antibacterial activity of Mg-1Al-0.25Cu was considerable. In summary, Mg-1Al-0.25Cu alloy with appropriate degradation rate, good biocompatibility and antibacterial properties can be introduced as a biodegradable orthopedic implant.

EVALUATION OF ANTIBACTERIAL PROPERTIES OF POLYLACTIC ACID-POLYCAPROLACTONE-CONTAINING HYDROXYAPATITE AND ZINC OXIDE NANOPARTICLES IN HARD TISSUE ABSORBABLE SCAFFOLDS
F. Dehghani Firoozabadi, A. Ramazani Saadatabadi, A. Asefnejad,
Volume 41, Issue 1 (8-2022)
Abstract
Today, many people need to use bone grafts and implants because of damage to bone tissue. Due to the stimulation of the immune system after implantation, infection at the operation site is very common, which causes swelling and pain in the operation area. The use of zinc oxide nanoparticles reduces infection at the operation site and reduces the patient's need for antibiotics. In the present study, the morphology of the scaffolds was investigated by field emission scanning electron microscope (FE-SEM). The toxicity of the samples was evaluated using MTT assay. The behavior of nanocomposites against Escherichia coli and Staphylococcus aureus was investigated by measuring the diameter of the growth inhibition zone. It was found that modification of scaffolds with nanoparticles caused a growth inhibition in bacterial culture medium. It was also observed that fibroblast cells on the surface of the modified scaffolds had longer survival than polymer scaffolds. This study showed that the addition of oxidizing nanoparticles improves the antibacterial properties of scaffolds and cell viability and reduces scaffold toxicity.

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