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Showing 3 results for Drug Delivery
Adsorption of Fluconazole Drug on Silica Aerogel‌ by Immersion Method and Investigation of the Rate and Mechanism of Drug Release
M. Afrashi, D. Semnani, Z. Talebi,
Volume 38, Issue 2 (9-2019)
Abstract
In this study, adsorption of fluconazole on silica aerogel was performed successfully by the immersion method in the 1% solution of fluconazole-ethanol at the ambient condition and without using the supercritical method. The hydrophobic and hydrophilic silica aerogels were synthesized by the two-stage sol-gel method and dried at the ambient temperature. This method had most of drug loading at 24 h. It was 1.92% and 1.98% for the hydrophilic and hydrophobic silica aerogels, respectively. Physical properties of the synthesized aerogels were studied by the nitrogen absorption and desorption tests. The presence of fluconazole and the chemical structure of the samples were determined by fourier-transform infrared spectroscopy (FTIR). As well, the loading and release of the drug were investigated using a spectrophotometer. The results showed the structure of the synthesized aerogels had a pore diameter of 6-8 nm and a surface area of about 800-100 m2/g. The study of the drug release also revealed that the release rate of fluconazole in the hydrophilic silica aerogel was higher than that of the hydrophobic sample.

Investigating the Release of Methotrexate and 5-Fluorouracil Anticancer Drugs from Multi-Layered Nanofiber Structure of Polycaprolactone/Chitosan
N. Poursharifi, D. Semnani, P. Soltani, S. Amanpour,
Volume 38, Issue 4 (1-2020)
Abstract
In this study, seven-layer nanofiber structures consisting of polycaprolactone/ chitosan polymers loaded with methotrexate and 5-fluorouracil anti-cancer drugs, for controlled drug delivery, were produced and evaluated. For this purpose, the second, fourth and sixth layers were loaded with drug and placed between the drug-free layers. The surface morphology of drug-free and drug-loaded nanofibers was investigated by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR) was used to study their chemical structure. The drug release rate in phosphate buffered saline (pH=7.4) and the released drug concentration were measured by spectrophotometry. Mechanical properties of single- and multi-layered samples were also investigated. SEM images showed formation of uniform and beadless fibers. FTIR spectrum confirmed presence of the drugs in the polymer mixture with no interaction. It was found that by increasing the chitosan content, a brittle structure with decreased elongation is formed. The release behavior of methotrexate and 5-Fluoracil drugs in neutral pH environment for 26 days was evaluated and the results exhibited a slow and sustained release.

Fabrication of Poly (Lactic Acid) Nanofiber Carrier Loaded with Dexamethasone Drug
S. Torabi, S. Khorshidi, A. Karkhaneh,
Volume 39, Issue 2 (8-2020)
Abstract
For many years, dexamethasone has been used as an anti-inflammatory drug and is still one of the safest glucocorticoids for treating various diseases. Due to the wide range of the side effects of this drug, it is essential to find a suitable delivering system for reduction in dosage with increased effectiveness. Electrospinning is one of the fiber fabrication methods which is widely used to develop drug carriers due to its ability to load various drugs and biological components and control their release. In this research, neat poly (lactic acid) electrospun fibers and dexamethasone loaded fibers were prepared. To evaluate the effect of polymer concentration on morphology, mechanical properties and drug release profile of the resulting fibers, three polymer concentrations of 10%, 14% and 18% w/v were processed. Thereafter, 5% w/v dexamethasone was added to solutions. The scanning electron microscopy images were investigated to obtain the average diameter of fibers and the average area of pores in each sample. In neat samples, by moving from 10% to 18% composition, the average diameter of the fibers increased by 63.21%. However, in drug loaded samples this increased by 51/19%. After evaluating mechanical properties, an increase of 81/34% in Elastic modulus by moving from 10% to 18% composition was observed. Moreover, the ultimate strength increased by 68/021% when increasing the polymer concentration from 10 to 18%. Drug release from the electrospun samples was continued up to 7 days. Linear release was observed in 10% and 14% compositions. The drug release pattern of these samples was of zero order. Considering the importance of zero order release in different applications of dexamethasone, these delivering systems could be useful. The maximum drug release rate belonged to 14% composition (0.044 1/h).

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