Volume 38, Issue 1 (Journal of Advanced Materials-Spring 2019)
2019, 38(1): 23-35 |
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Sohrabi M, Abbasi M, Ansar M M. Fabrication of Poly(ε-Caprolactone), Hydrophilic and β-Tricalcium Phosphate Layer- by -Layer Nanofibrous Scaffolds for Tissue Engineering. Journal of Advanced Materials in Engineering (Esteghlal) 2019; 38 (1) :23-35
URL: http://jame.iut.ac.ir/article-1-980-en.html
URL: http://jame.iut.ac.ir/article-1-980-en.html
1. Faculty of Engineering, Department of Textile Engineering, University of Guilan, Gilan, Iran. , m.abbasi@guilan.ac.ir
Abstract: (7952 Views)
In this study, using biodegradable polymers, nanofiberouse scaffolds were fabricated from the layer-by-layer electrospinning method, including two layer that poly (ε-caprolactone), polyvinylpyrrolidone deposited at first layer and poly (ε-caprolactone), polyvinyl alcohol , β-tricalcium phosphate at latter. After prepration of scaffolds, scanning electron microscopy (SEM), swelling, porosity, mechanical properties and biodegradability behavior in buffered saline phosphate solution were studied. The results confirmed the bioactivity and suitable mechanical properties of the layer-by-layer scaffold. The swelling increase with the addition of hydrophilic polymers and reache 811 ± 214 % in the layer-by-layer scaffold, which reveald a significant difference compared to pure PCL. The MTT test on the layer-by-layer scaffold, after 3, 5 and 7 days of rats bone marrow stem cells (rMSC) culture, showed the cell viability of above 80% moreover, cells morphology on the scafold indicated the optimal compatibility of cells on the scaffold.
Keywords: Scaffold, Layer- by -layer electrospinning, Poly(ε-caprolactone), β-Tricalcium phosphate, Tissue engineering.
Type of Study: Research |
Subject:
Polymer materials
Received: 2018/07/3 | Accepted: 2018/12/16 | Published: 2019/06/15
Received: 2018/07/3 | Accepted: 2018/12/16 | Published: 2019/06/15
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